Research team JBC discovers new mechanism for cancer cell metastasis

<p> Candida albicans (Candida albicans) is an important opportunistic fungus in the human body, usually symbiotic in healthy people does not cause any adverse reactions, but in immunocompromised people may cause organ mucosal infection and life-threatening blood infection. In recent years, due to the widespread use of broad-spectrum antibiotics, the application of new medical technologies such as cancer chemotherapy and organ transplantation, the prevalence of AIDS and the aging of the population, fungal infections mainly caused by Candida albicans have become an increasingly serious clinical problem . A thorough understanding of the body's immune mechanism against Candida albicans is of great significance for the development of effective antifungal treatments.

Pattern recognition receptors (PRRs) are a class of recognition molecules that are mainly expressed on the surface of innate immune cells, endosomes, lysosomes, and cytoplasm, and can recognize one or more PAMPs / DAMPs. The mutual recognition and action of pathogen-associated molecular patterns (PAMP) on the surface of microorganisms is the key to initiating innate immune responses. At present, PRRs involved in Candida albicans recognition are mainly classified into Toll-like receptors and non-Toll-like receptors. Non-Toll-like receptors include C-type lectin receptors and complement receptor families.

C-type lectin receptors are characterized by the presence of a C-typelectin like domains (CTLDs), capable of identifying endogenous ligands and pathogens obtained by endocytosis or phagocytosis, within maintenance Derived glycoproteins play an important role in the stability, antibody presentation and phagocytosis. Type C lectin receptors are pattern recognition receptors, some of which are involved in antifungal immunity.

In this article, the researchers confirmed that a previously uncharacterized C-type lectin receptor Dectin-3 (also known as CLECSF8, MCL, or Clec4d) identified α-mannans on the surface of Candida albicans hyphae and induced NF-B activation. Mice that block or genetically delete Dectin-3 are highly sensitive to Candida albicans infection. Subsequently, the researchers confirmed that Dectin-3 formed a heterodimer with Dectin-2, a characteristic C-type lectin receptor, to recognize Candida albicans hyphae. Compared to their respective homodimers, Dectin-3 and Dectin-2 heterodimers are able to bind α-mannans more effectively, contributing to a powerful inflammatory response against fungal infections.

New research confirms that Dectin-3 and Dectin-2 form a heterodimeric PRR to sense fungal infections, indicating that different C-type lectin receptors may form different heterologous or homodimers, resulting in The host cell detects the different sensitivities and diversity of various microbial infections.

Leather Cosmetic Bag

New Women'S Cosmetic Bag,Multi Functional Cosmetic Bag,Hot Women'S Cosmetic Bags,Discount Women'S Cosmetic Bag

Dongguan City Diadia Industry Co.,Ltd , https://www.diadiabag.com