Mechanism of cytomegalovirus evading the immune system

Viruses have many tricks to evade the immune system. In the Journal of Cell Biology on September 7, 2009, Stagg et al. Revealed key details of one of these viral tricks. The virus recognizes a protein that allows cytomegalovirus to turn off the body's defenses.

Cytomegalovirus can avoid the surveillance of the immune system by targeting the MHC I protein. When the body is infected, MHC I will capture a small amount of viral protein and present it to virin T cells, thereby killing the cells and stopping the infection. However, the two cytomegalovirus genes will trick the cell to pan-hormone MHC I and destroy it in the proteasome. In order to cause pan-hormonalization of MHC I, the gene will select a protein called E3 ligase. The researchers explained that at present, the identity of this protein is not very clear.

Using RNA interference technology, Stagg screened 373 candidates and found that a ligase called TRC8 protects MHC I. TRC8 mutants can truncate pan-hormonalization and restore MHC I function.

   Stainless Steel Spice Rack!!!!TOP quality stainless steel body,durable in use,brushed stainless steel styling with magnetic. stainless steel  base.Raw material: Stainless steel 18/10,Size: 14*14*28cm.polished exterior with shiny appearance and easy to clean,make your life comfortable and healthy.innovative and functional design.fashional and popular cooking and pouring concept.High Quality Rack,Bottom can rotation,Packing: 3-layers color box,6pcs/ctn,69.5*28*36cm.


Stainless Steel Spice Rack

Stainless Steel Spice Rack,16Pcs Stainless Steel Spice Rack,Stainless Steel Spice Rack 12Pcs,Stainless Steel Wall Spice Rack


Posted on