With the support of the National Natural Science Foundation of China, the Ministry of Science and Technology and the Chinese Academy of Sciences, researchers from the Key Laboratory of the Institute of Organic Solids of the Institute of Chemistry prepared a new type of bioadhesive interface for targeted identification of cancer cells. The cooperation of personnel has realized the high-efficiency capture and release of target cancerous lymphocytes. Related research results were published in the recent "Advanced Materials" (Adv. Mater. 2011, 23, 4376), and were selected as cover papers for a special introduction.
The interaction between the cell and the surface of the material is one of the most important scientific issues in the fields of biological interfaces, materials, and medicine. Recently, compared with the traditional two-dimensional plane, the three-microstructure surface has attracted extensive attention from researchers because it is closer to the real physiological environment. In the previous work, the researchers found that the three-dimensional nano-substrate can effectively improve the capture efficiency of circulating tumor cells in the blood, and collaborated with researchers at the University of California School of Medicine to successfully isolate and detect circulating tumor cells from patient blood samples ( Angew. Chem. Int. Ed. 2011, 50, 3084).
On this basis, they modified a nucleic acid aptamer that can specifically adsorb cancerous lymphocytes on the silicon nanowire array substrate obtained by chemical etching. Due to the synergistic effect of molecular recognition and structural recognition, high-efficiency capture of target lymphocytes is achieved, and its capture efficiency is two orders of magnitude higher than that of traditional two-dimensional materials. In addition, just use the exonuclease to cut the single-stranded nucleic acid aptamer molecules, the captured cells can be effectively released, avoiding the damage of cells caused by pancreatin in the traditional de-adhesion process.
After the study was published in "Advanced Materials", it was reported by Wiley Press's Material view of China. This new chip provides a "high-capture, easy-to-release" cell detection platform, which has great application prospects in the diagnosis of major cell-based diseases such as HIV detection, cancer detection, and stem cell separation. Recently, researchers were also invited to write a chapter entitled Emerging Nanotechnology for Efficient Capture of Circulating Tumor Cells for Nanomedicine in Diagnostics published by Science Publishers (Nanomedicine in Diagnostics, Chp 8, 172-190).
Current cover of "Advanced Materials" magazine
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