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Recently, a study published in the journal Annals of Clinical and Translational Neurology found that extra virgin olive oil in the Mediterranean diet prevented cognitive decline. Studies have shown that premium olive oil consumption protects memory and learning, reducing the formation of beta-amyloid plaques and neurofibrillary tangles in the brain.
The Mediterranean diet is considered a healthy eating habit. Previous studies have shown that it can delay cognitive decline in the elderly and prevent brain atrophy in the elderly. Recently, researchers at Temple University's Louis Katz School of Medicine (LKSOM) discovered a special ingredient in the Mediterranean diet that prevents cognitive decline: extra virgin olive oil. The study, published June 21 in the journal Annals of Clinical and Translational Neurology, showed that premium olive oil consumption protects memory and learning, reducing the formation of beta-amyloid plaques and neurofibrillary tangles in the brain. Both are classic biomarkers of Alzheimer's disease.
"We found that olive oil can reduce brain inflammation, but the most important thing is to activate the autophagy process," said study author Domenico Praticò. Autophagy is the process by which cells break down and clear intracellular debris and toxins such as amyloid plaques and tau tangles.
Previous studies have shown that the widespread use of extra virgin olive oil in the Mediterranean diet has many health benefits. Dr. Praticò said: “The idea is that extra virgin olive oil is better than fruits and vegetables alone, and as a monounsaturated vegetable fat is healthier than saturated animal fat.â€
To test the relationship between extra virgin olive oil and dementia, Dr. Praticò and his colleagues used a mouse model of Alzheimer's disease. The researchers divided the animals into two groups, one given a diet rich in extra virgin olive oil and the other receiving a regular diet without extra virgin olive oil. When the mice were 6 months old, symptoms of Alzheimer's disease began to appear before the introduction of olive oil into the diet.
The study found that mice fed a diet rich in extra virgin olive oil performed better at tests of working memory, spatial memory and learning ability at 9 and 12 months of age. In addition, brain tissue from both groups of mice showed significant differences in the appearance and function of nerve cells.
Dr. Praticò said: “The most obvious difference is the integrity of the synapse. The synaptic integrity of mice fed a diet rich in extra virgin olive oil is better. In addition, compared to regular diet mice, the consumption of olive oil The autophagy activity of mouse brain cells is significantly increased and eventually leads to a decrease in the levels of amyloid plaques and phosphorylated tau."
Dr. Praticò explained: “This is an exciting finding for us. Since autophagy is activated, memory and synaptic integrity are preserved, and the pathological symptoms of Alzheimer's disease model mice are significantly reduced. This is a Very important finding, because we suspect that the reduction in autophagy marks the beginning of Alzheimer's disease."
Dr. Praticò and colleagues plan to add extra virgin olive oil to the diet at the age of 12 months in the same mouse, when they have beta-amyloid plaques and neurofibrillary tangles. Dr. Praticò added: “The disease usually occurs when a patient is suspected of having Alzheimer's disease and goes to the doctor. We want to know if adding olive oil to the diet after the disease can stop or reverse Alzheimer's disease.â€
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